Order of Russian Government 521n from 08.08.2016 main points:

1. Terms prolongation (government people work for changing process was 10 working days – become 15, for duplicates was 3 working days – become 7),
2. Government fee for expertise process must be paid before documents submission to Roszdravnadzor (well-known fact but first official issue in law),
3. Original of registration certificate is evidence of registration process (that’s why it is not enough to have registration certificate in electronic view even if information about your registration certificate is in official Roszdravnadzor database),
4. Second original of registration certificate will not be stored in Roszdravnadzor storage with registration dossier (as it was before). It could be the first step to electronic dossier.